Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database.

Objective: This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023. Methods: Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were collected. After standardizing the data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, were employed for analysis. Results: Among 2535 ADE reports where cenobamate was the primary suspected drug, 94 adverse reactions involving 11 different System Organ Class (SOC) categories were identified through the application of four signal quantification techniques. More specifically, neurological disorders and injuries resultant from complications are frequent adverse reactions associated with cenobamate. Conclusion: Our research findings align with established results, affirming the favorable safety profile of cenobamate. Effective prevention of adverse reactions induced by cenobamate can be achieved through the establishment of efficient blood concentration monitoring and dose adjustments.

Atom-Economical Applications of Diaryliodonium Salts.

Diaryliodonium salt, as a stable and easily prepared reagent, has become one of the most efficient arylation reagents in organic synthesis. In traditional methods, this reagent is generally applied as a single arylation source and the regenerated aryl iodide is a waste of resources. In the past five years, transition-metal-catalyzed utilization of both aryl groups in diaryliodonium salts has been well demonstrated. The purpose of the present review is to focus on various atom-economical applications of diaryliodonium salt methodologies that have been reported recently for the synthesis of functionalized molecules. The presentation is organized according to the structures of the diaryliodonium salts and the reaction components.